Moeljono M P, Bazer F W, Thatcher W W
Prostaglandins. 1976 Apr;11(4):737-43. doi: 10.1016/0090-6980(76)90073-3.
Experiments were conducted to determine if prostaglandin F2alpha (PGF2alpha) is luteolytic in swine. In Experiment 1, four bilaterally hysterectomized gilts were injected with PGF2alpha at 0800 (10mg) and 2000 hours (10mg) and four gilts received .9% saline at the same times on day 17 after onset of estrus. Treatments were reversed in the two groups of gilts 21 days later. All eight PGF2alpha treated gilts exhibited estrus an average of 88.0 +/- 13.5 hours after treatment and average duration of estrus was 66.0 +/- 16.4 hours. Saline treated controls did not exhibit estrus. Two additional gilts were hysterectomized bilaterally and the saphenous artery catheterized on day 7 after onset on estrus. PGF2alpha injected on day 17 resulted in a precipitous decline in plasma progestin concentration and onset of estrus by 110 and 90 hours in gilts 1 and 2, respectively. Another bilaterally hysterectomized gilt, with CL marked with India ink, received PGF2alpha on day 17. Estrus occurred 92 hours later and, on day 4, regression of marked CL to corpora albicantia and presence of newly formed CL was confirmed at laparotomy. In Experiment 2, 12 bilaterally hysterectomized gilts were treated with PGF2alpha at 0800 (10mg) and 2000 hours (10mg) on either day 8, 11, 14 or 17 after onset of estrus. None of the gilts treated on days 8 and 11 exhibited estrus. Two of three gilts treated on day 14 and all three gilts treated on day 17 exhibited estrus at an average of 116.0 +/- 9.8 hours post-treatment. Average duration of estrus was 49.6 +/- 8.8 hours.
进行了多项实验以确定前列腺素F2α（PGF2α）对母猪是否具有溶黄体作用。在实验1中，4头双侧子宫切除的后备母猪于发情开始后的第17天，在08:00（10毫克）和20:00（10毫克）分别注射PGF2α，另有4头后备母猪在相同时间注射0.9%的生理盐水。21天后，两组后备母猪的处理方式互换。所有8头接受PGF2α处理的后备母猪在处理后平均88.0±13.5小时出现发情，发情平均持续时间为66.0±16.4小时。接受生理盐水处理的对照组未出现发情。另外2头后备母猪在发情开始后的第7天进行双侧子宫切除并对隐动脉进行插管。在第17天注射PGF2α后，后备母猪1和后备母猪2的血浆孕酮浓度急剧下降，分别在110小时和90小时开始发情。另一头双侧子宫切除的后备母猪，其黄体用印度墨水标记，在第17天接受PGF2α注射。92小时后出现发情，在第4天，剖腹术证实标记的黄体退化形成白体，且存在新形成的黄体。在实验2中，12头双侧子宫切除的后备母猪在发情开始后的第8、11、14或17天的08:00（10毫克）和20:00（10毫克）接受PGF2α处理。在第8天和第11天接受处理的后备母猪均未出现发情。在第14天接受处理的3头后备母猪中有2头发情，在第17天接受处理的所有3头后备母猪在处理后平均116.0±9.8小时出现发情。发情平均持续时间为49.6±8.8小时。
