使用苯肾上腺素刺激的兔输卵管灌注模型对PGA2、PGE1和PGE2进行剂量反应比较。

A dose-response comparison of PGA2, PGE1 and PGE2 using the phenylephrine-stimulated perfused oviduct of the rabbit.

作者信息

Heilman R D, Strainer S M

出版信息

Prostaglandins. 1976 Jul;12(1):139-48. doi: 10.1016/s0090-6980(76)80012-3.

Abstract

The phenylephrine-stimulated perfused oviduct of the rabbit was evaluated as a model for studying the activity of prostaglandins that produce inhibition of the oviducal smooth muscle. Elevation of the normal "tone" of the oviduct by perfusing phenylephrine through the lumen permitted quantitation of the responses to PGA2, PGE1 and PGE2 by measuring the magnitude of the inhibitory response produced by the agents. PGE2 was relatively more potent, efficacious and specific for the oviduct than PGA2 or PGE1. It was concluded that the model was suitable for comparative dose-response studies of PGA2, PGE1 and PGE2 and their analogs.

摘要

将苯肾上腺素刺激的兔输卵管灌注模型用于研究产生输卵管平滑肌抑制作用的前列腺素的活性。通过向管腔内灌注苯肾上腺素来提高输卵管的正常“张力”，从而通过测量这些药物产生的抑制反应幅度来定量评估对PGA2、PGE1和PGE2的反应。PGE2相对于PGA2或PGE1对输卵管而言效力更强、效果更好且更具特异性。得出的结论是，该模型适用于PGA2、PGE1和PGE2及其类似物的比较剂量反应研究。