Heilman R D, Strainer S M
Prostaglandins. 1976 Jul;12(1):127-37. doi: 10.1016/s0090-6980(76)80011-1.
The dose-response effect of PGF2alpha on the perfused oviduct of estrous and ovariectomized rabbits was determined. The oviducts of ovariectomized rabbits were more sensitive to the contractile effects of PGF2alpha than those of estrous rabbits. This was demonstrated by a significant difference in the slope of the dose-response curves and in the magnitude of the maximum responses between the two groups. Blood pressure responses (depressor) to PGF2alpha were not affected by the reproductive hormonal status of the rabbits. The oviduct (estrous rabbits) developed tachyphylaxis to the effect of PGF2alpha. It was concluded that the response of the rabbit oviduct to PGF2alpha is dependent on the reproductive hormone status of the animal and that the oviduct becomes insensitive to the effects of PGF2alpha with repeated administration.
测定了PGF2α对发情期和去卵巢家兔灌注输卵管的剂量反应效应。去卵巢家兔的输卵管对PGF2α的收缩效应比发情期家兔的更敏感。这通过两组之间剂量反应曲线的斜率和最大反应幅度的显著差异得到证明。家兔对PGF2α的血压反应（降压）不受生殖激素状态的影响。（发情期家兔的）输卵管对PGF2α的作用产生快速耐受性。得出的结论是，家兔输卵管对PGF2α的反应取决于动物的生殖激素状态，并且输卵管在反复给药后对PGF2α的作用变得不敏感。
