致病性大肠杆菌O157:H7的突变体与长期分子进化
Mutators and long-term molecular evolution of pathogenic Escherichia coli O157:H7.
作者信息
Whittam T S, Reid S D, Selander R K
机构信息
Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802, USA.
出版信息
Emerg Infect Dis. 1998 Oct-Dec;4(4):615-7. doi: 10.3201/eid0404.980411.
Abstract
It has been proposed that an increased mutation rate (indicated by the frequency of hypermutable isolates) has facilitated the emergence of Escherichia coli O157:H7. Analysis of the divergence of 12 genes shows no evidence that the pathogen has undergone an unusually high rate of mutation and molecular evolution.
摘要
有人提出，突变率增加（以超突变菌株的频率表示）促进了大肠杆菌O157:H7的出现。对12个基因的分歧分析表明，没有证据表明该病原体经历了异常高的突变率和分子进化。
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