Culham D E, Wood J M
Department of Microbiology, University of Guelph, Guelph, ON N1G 2W1, Canada.
J Bacteriol. 2000 Nov;182(21):6272-6. doi: 10.1128/JB.182.21.6272-6276.2000.
Chromosomal DNAs of enterohemorrhagic, uropathogenic, and laboratory attenuated Escherichia coli strains differ in the rpoS-mutS region. Many uropathogens lack a deletion and an insertion characteristic of enterohemorrhagic strains. At the same chromosomal position, they harbor a 2.1-kb insertion of unknown origin with a base composition suggestive of horizontal gene transfer. Unlike virulence determinants associated with urinary tract infection and/or neonatal meningitis (pap or prs, sfa, kps, and hly), the 2.1-kb insertion is shared by all group B2 strains of the E. coli Reference Collection.
肠出血性、尿路致病性和实验室减毒大肠杆菌菌株的染色体DNA在rpoS-mutS区域存在差异。许多尿路致病菌缺乏肠出血性菌株特有的缺失和插入。在相同的染色体位置,它们含有一个来源不明的2.1 kb插入片段,其碱基组成提示水平基因转移。与尿路感染和/或新生儿脑膜炎相关的毒力决定因素(pap或prs、sfa、kps和hly)不同,大肠杆菌参考菌株库中所有B2组菌株都有这个2.1 kb的插入片段。