Beutin L, Zimmermann S, Gleier K
Robert Koch-Institut, Abt. Mikrobiologie, Berlin, Germany.
Emerg Infect Dis. 1998 Oct-Dec;4(4):635-9. doi: 10.3201/eid0404.980415.
We investigated different types of Shiga toxin-producing Escherichia coli (STEC) not belonging to serogroup O157 for their role as human pathogens. Non-O157 STEC isolated from 89 human patients in Germany were characterized according to serotypes, virulence markers, and association with human illness. EaeA-positive STEC were isolated from 54 (60.7%) of the patients and were frequently associated with severe diarrheal disease, hemolytic uremic syndrome, and young age. EaeA-negative STEC were found in 35 (39.3%) of the patients and were more associated with clinically uncomplicated cases and adult patients. For pediatric patients, a serotype-independent diagnosis of STEC is recommended.
我们研究了不属于O157血清群的不同类型产志贺毒素大肠杆菌（STEC）作为人类病原体的作用。从德国89名人类患者中分离出的非O157 STEC，根据血清型、毒力标记以及与人类疾病的关联进行了特征分析。从54名（60.7%）患者中分离出了EaeA阳性STEC，其常与严重腹泻病、溶血尿毒综合征以及年轻患者相关。在35名（39.3%）患者中发现了EaeA阴性STEC，其更多地与临床症状不复杂的病例以及成年患者相关。对于儿科患者，建议进行不依赖血清型的STEC诊断。
