Gulcicek Osman Bilgin, Ozdogan Kamil, Solmaz Ali, Yigitbas Hakan, Altınay Serdar, Gunes Aysegul, Celik Duygu Sultan, Yavuz Erkan, Celik Atilla, Celebi Fatih
General Surgery Clinic, Bagcilar Training and Research Hospital, Istanbul, Turkey;
General Surgery Clinic, Bagcilar Training and Research Hospital, Istanbul, Turkey.
Food Nutr Res. 2016 Apr 15;60:30888. doi: 10.3402/fnr.v60.30888. eCollection 2016.
Obesity has recently become a major health problem, and researchers have been directed to work toward the development of surgical techniques, with new mediators playing an important role in nutrition. Gastric plication (GP) and sleeve gastrectomy (SG) have become popular recently. These are widely used techniques in bariatric surgery.
In this study, we aimed to compare the efficiency of SG and GP techniques on rats.
Wistar-Hannover rats (n=18) were divided into three equal groups, namely SG, GP, and control. Blood samples were taken before the operation and on the 30th day after the operation. The weights of all rats were recorded both on first day and the 30th day after the operation. Serum gastrin, ghrelin, and leptin levels were also measured on the same days. For histopathological examination, gastrectomy was performed after the animals were sacrificed.
Average weight loss was 10% for the SG group and 6.5% for the GP group. One month after the operations, the decrease in the ghrelin and leptin levels of GP and SG groups was significant compared with the levels of the control group. Gastrin levels of the SG group increased significantly compared with those of the control group. Histopathological examination revealed that there was significant decrease in the ghrelin and leptin levels of the GP and SG groups compared with those of the control group. Foveolar hyperplasia (FH), cystic glandular dilatation, and fibrosis were significantly higher in the GP and SG groups compared with the control group.
Although GP is not as effective as SG in terms of weight loss, it provides the same effectiveness in decreasing ghrelin and leptin levels. Histopathological findings revealed that FH, fibrosis, and the cystic glandular dilatation development rates were similar.
肥胖最近已成为一个主要的健康问题，研究人员一直致力于开发手术技术，新的介质在营养方面发挥着重要作用。胃折叠术（GP）和袖状胃切除术（SG）最近变得很流行。这些是减肥手术中广泛使用的技术。
在本研究中，我们旨在比较SG和GP技术对大鼠的效果。
将Wistar-Hannover大鼠（n = 18）分成三个相等的组，即SG组、GP组和对照组。在手术前和手术后第30天采集血样。记录所有大鼠在手术第一天和手术后第30天的体重。在同一天还测量血清胃泌素、胃饥饿素和瘦素水平。为了进行组织病理学检查，在动物处死后进行胃切除术。
SG组的平均体重减轻为10%，GP组为6.5%。手术后一个月，与对照组相比，GP组和SG组的胃饥饿素和瘦素水平显著降低。与对照组相比，SG组的胃泌素水平显著升高。组织病理学检查显示，与对照组相比，GP组和SG组的胃饥饿素和瘦素水平显著降低。与对照组相比，GP组和SG组的小凹增生（FH）、囊性腺体扩张和纤维化明显更高。
虽然GP在减肥方面不如SG有效，但它在降低胃饥饿素和瘦素水平方面具有相同的效果。组织病理学结果显示，FH、纤维化和囊性腺体扩张的发生率相似。
