Mitchell J B, Laiacona J
Department of Psychology, Boston College, Chestnut Hill, MA 02167-3807, USA.
Behav Brain Res. 1998 Dec;97(1-2):107-13. doi: 10.1016/s0166-4328(98)00032-1.
Evidence from several sources indicates that the frontal cortex is involved in memory involving time, or temporal memory, and in behavioral sequencing. Rats were presented with two familiar objects and the amount of exploration directed at each was recorded. Subjects directed more exploration at the object encountered further ago in the past, even though the two objects differed by only 1 h. After bilateral medial frontal cortex lesion, animals did not differentiate between old and recent objects. Performance on an object recognition test (novel versus familiar objects) that also used exploration time did not change as a result of the medial frontal cortex lesions.
来自多个来源的证据表明，前额叶皮层参与涉及时间的记忆，即时间记忆，以及行为序列。给大鼠呈现两个熟悉的物体，并记录针对每个物体的探索量。尽管两个物体仅相差1小时，但实验对象对过去更早遇到的物体进行了更多的探索。双侧内侧前额叶皮层损伤后，动物无法区分新旧物体。同样使用探索时间的物体识别测试（新物体与熟悉物体）的表现并未因内侧前额叶皮层损伤而改变。
