Mazurkiewicz-Kwilecki I, Henwood R W
Agents Actions. 1976 Jul;6(4):402-8. doi: 10.1007/BF01973210.
Chronic but not acute treatment with morphine resulted in a significant decrease in the histamine concentration in the rat hypothalamus while a slight decrease was noted in the brain stem and cortex. Naloxone precipitated morphine withdrawal caused a significant decrease in histamine concentration in all three brain regions investigated. Withdrawal of morphine resulted in a further significant decrease in histamine level in the hypothalamus, brain stem and cortex. Substitution of morphine by methadone induced changes similar to these seen in rats chronically treated with morphine alone. The present data suggest that in addition to the other biogenic amines histamine may be involved in the pharmacological effects of morphine.
吗啡的慢性而非急性治疗导致大鼠下丘脑组胺浓度显著降低，而脑干和皮层中的组胺浓度略有下降。纳洛酮诱发的吗啡戒断导致所研究的所有三个脑区的组胺浓度显著降低。吗啡戒断导致下丘脑、脑干和皮层中的组胺水平进一步显著降低。用美沙酮替代吗啡引起的变化与仅用吗啡长期治疗的大鼠中观察到的变化相似。目前的数据表明，除其他生物胺外，组胺可能参与吗啡的药理作用。
