Yu X, Yang Z, Xu S
Department of Orthopedic Surgery, 1st University Hospital, West China University of Medical Sciences, Chengdu, Sichuan, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 1997 May;11(3):153-6.
A kind of Chinese herb medicine--Wumingyi chongji could promote fracture healing had been proved. In order to disclose the mechanism, a standard fracture model was produced in 50 healthy male Newzealand rabbits. The animals were randomly divided into experimental group and control group. Another 5 rabbits without operation act as nomal. By immunohistochemical study, the bone morphogenetic protein (BMP) content in callus was calculated by computerized interacive morphometry (CIM) in the 1st, 2nd, 3rd, 4th, 5th week after fracture. The results were: BMP in callus was much more than in nomal (P < 0.01); BMP in callus increased from the 1st week to the 3rd week, decreased from 4th week to 5th week, and was more in experimental group in the 1st and 2nd week than in the control group (P < 0.01). The highest BMP content appeared in the 2nd week in the experimental group, while in the 3rd week in the control group. It was concluded that Wumingyi chongji could promote osteoblast to synthetize BMP, BMP induce preosteoblast change into osteoblast. Thus the rate of fracture healing could be increased.
一种中草药——无名异冲剂能促进骨折愈合已得到证实。为揭示其机制，在50只健康雄性新西兰兔身上建立标准骨折模型。动物被随机分为实验组和对照组。另外5只未做手术的兔子作为正常对照。通过免疫组化研究，在骨折后第1、2、3、4、5周，采用计算机交互式形态计量学（CIM）计算骨痂中骨形态发生蛋白（BMP）的含量。结果显示：骨痂中的BMP含量远高于正常组（P<0.01）；骨痂中的BMP含量从第1周开始升高至第3周，从第4周开始下降至第5周，且在第1周和第2周实验组中的BMP含量高于对照组（P<0.01）。实验组中BMP含量在第2周达到最高，而对照组在第3周达到最高。结论是无名异冲剂能促进成骨细胞合成BMP，BMP诱导前成骨细胞转变为成骨细胞。从而可提高骨折愈合速度。
