Zhou J, Song Y, Wang Y
Department of Plastic Surgery, First Affiliated Hospital of Shantou University Medical School, Shantou, P.R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 1997 Sep;11(5):267-8.
In order to investigate the function of epidermal growth factor (EGF), the following experiments were performed. Thirty white rats were chosen and divided into 3 groups. In the back of each rat, two 2 cm x 2 cm wounds were made bilaterally, the skin and subcutaneous tissue was removed. EGF were used in one of the two wounds randomly, while those without EGF usage in control. After 1, 2 and 3 weeks, the rats were sacrificed. The area of the wounds was measured, and the healing time of each wound was recorded. The results showed that the healing time of EGF group was 14.6 days while that of control group was 18.5 days (P < 0.01). Furthermore, the DNA, protein and hydroxyproline contents of EGF group were higher than those of the control group (P < 0.01). It was suggested the EGF could accelerate wound healing and shorten the healing time.
为了研究表皮生长因子（EGF）的功能，进行了以下实验。选取30只白色大鼠，分为3组。在每只大鼠的背部双侧制作两个2厘米×2厘米的伤口，去除皮肤和皮下组织。随机在两个伤口中的一个使用EGF，另一个不使用EGF作为对照。1、2和3周后，处死大鼠。测量伤口面积，记录每个伤口的愈合时间。结果显示，EGF组的愈合时间为14.6天，而对照组为18.5天（P<0.01）。此外，EGF组的DNA、蛋白质和羟脯氨酸含量均高于对照组（P<0.01）。提示EGF可加速伤口愈合，缩短愈合时间。
