Li H, Zhao W, Zheng X
Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Binzhou Medical College, Shangdong.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 1997 Mar;11(2):72-5.
To understand the reason of hyperpigmentation following full-thickness skin autograft, 54 guinea pigs were selected as skin autograft models. The changes of density of epidermal keratinocyte (KC) and the amount and distribution of melanin in the epidermal KC were observed by histological, histochemical and autoradiographic techniques. The results showed: (1) The histological changes of KC were in fact a wound-repair process; (2) The increased melanin in KC coordinated with "multi-overlapping screen" effect, a result of multiple layers of "supranuclear cap", was the direct cause of hyperpigmentation of the graft and (3) The hydrolytic disturbance of melanin in KC and the longer life span of the KC were probably the important reasons for the increase of melanin in the epidermis.
为了解全厚皮片自体移植后色素沉着的原因，选取54只豚鼠作为皮肤自体移植模型。采用组织学、组织化学和放射自显影技术观察表皮角质形成细胞（KC）密度的变化以及表皮KC中黑色素的含量和分布。结果显示：（1）KC的组织学变化实际上是一个伤口修复过程；（2）KC中黑色素增加与“多层重叠屏障”效应相关，“多层核上帽”导致了移植物色素沉着，这是移植物色素沉着的直接原因；（3）KC中黑色素的水解紊乱以及KC较长的寿命可能是表皮中黑色素增加的重要原因。
