Duan S, Luo J, Liu F
Department of Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1997;22(1):78-80.
The levels of tumor necrosis factor a (TNF alpha) and phospholipase A2 (PLA2) in peripheral blood were determined by means of the ELISA and improved micromethod in 31 patients with urmia and 12 normal healthy persons. The results showed: 1. In non-dialysis group and during a single dialysis session, a significant increase in the levels of TNF alpha was observed. 2. In non-dialysis and peritoneal dialysis patients, serum levels of PLA2 were significantly increased compared to normal subjects. The results suggest that acute complications induced by hemodialysis are related to increasing levels of TNF alpha, souble PLA2 in cleared by hemodialysis.
采用酶联免疫吸附测定法（ELISA）和改良微量法，对31例尿毒症患者和12名正常健康人的外周血中肿瘤坏死因子α（TNFα）和磷脂酶A2（PLA2）水平进行了测定。结果显示：1. 在非透析组及单次透析过程中，观察到TNFα水平显著升高。2. 与正常受试者相比，非透析患者和腹膜透析患者的血清PLA2水平显著升高。结果提示，血液透析引起的急性并发症与TNFα水平升高有关，可溶性PLA2可被血液透析清除。
