Peuravuori H J, Funatomi H, Nevalainen T J
Department of Pathology, University of Turku, Finland.
Eur J Clin Chem Clin Biochem. 1993 Aug;31(8):491-4. doi: 10.1515/cclm.1993.31.8.491.
Time-resolved fluoroimmunoassays were used for the detection of pancreatic group I and synovial-type group II phospholipases A2 in sera of patients suffering from chronic renal failure before and after haemodialysis. The concentration of group I phospholipase A2 was ten-fold higher in sera of uraemic patients than in healthy controls. There was no significant difference in the concentrations of group I phospholipase A2 in serum before and after haemodialysis. The concentration of group II phospholipase A2 was only marginally increased in sera of uraemic patients, compared with healthy controls. There was no significant difference in the concentrations of group II phospholipase A2 before and after haemodialysis. The results indicate that the metabolism of group I phospholipase A2 differs from that of group II phospholipase A2 in chronic renal failure.
采用时间分辨荧光免疫分析法检测慢性肾衰竭患者血液透析前后血清中Ⅰ型胰腺型和Ⅱ型滑膜型磷脂酶A2。尿毒症患者血清中Ⅰ型磷脂酶A2的浓度比健康对照者高10倍。血液透析前后血清中Ⅰ型磷脂酶A2的浓度无显著差异。与健康对照者相比，尿毒症患者血清中Ⅱ型磷脂酶A2的浓度仅略有升高。血液透析前后Ⅱ型磷脂酶A2的浓度无显著差异。结果表明，在慢性肾衰竭中，Ⅰ型磷脂酶A2的代谢与Ⅱ型磷脂酶A2的代谢不同。
