Seggie J, Brown G M
Biol Psychiatry. 1976 Oct;11(5):583-97.
In order to characterize the effects of a septal lesion on plasma growth hormone levels, blood samples were taken from normal and sham-operated rats and rats with a bilateral septal lesion under conditions of rest and following stressful stimulation. Nonlesioned control rats evidenced a significant base line diurnal rhythm in plasma growth hormone levels which was unaffected by a septal lesion. In response to stress, plasma growth hormone levels evidenced a significant drop. Minimum levels were reached 15 min after stimulation and remained depressed during 1 hr of observation after stimulation. Rats with a septal lesion evidenced the same pattern of growth hormone response to stressful stimulation as nonlesioned rats, however the magnitude of response was potentiated in septal rats. The present data were compared to the previously published corticosterone data from the same animals. A septal lesion has similar effects on boting 24-hour rhythm of either of these hormones but potentiated the response of both corticosterone and growth hormone to stress even though the direction of response is opposite. The results are interpreted as suggesting the septum is an element in some central coping mechanism which is involved when an organism reacts to environmental demands. Preliminary data further suggest that the same central coping mechanism is involved in both the behavioral and hormonal responses to stress.
为了描述隔区损伤对血浆生长激素水平的影响，在静息状态和应激刺激后，从正常大鼠、假手术大鼠和双侧隔区损伤大鼠采集血样。未损伤的对照大鼠血浆生长激素水平呈现明显的基线昼夜节律，且不受隔区损伤的影响。对应激的反应是，血浆生长激素水平显著下降。刺激后15分钟达到最低水平，并在刺激后的1小时观察期内持续降低。隔区损伤的大鼠对应激刺激的生长激素反应模式与未损伤大鼠相同，然而，隔区大鼠的反应幅度增强。将目前的数据与先前发表的来自同一动物的皮质酮数据进行比较。隔区损伤对这两种激素的24小时节律都有类似影响，但即使反应方向相反，隔区损伤也增强了皮质酮和生长激素对应激的反应。结果被解释为表明隔区是某种中枢应对机制的一个组成部分，当机体对环境需求做出反应时该机制会被激活。初步数据进一步表明，相同的中枢应对机制参与了对应激的行为和激素反应。
