刺五加皂苷A和I对人类致病真菌的生长抑制活性。

Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi.

作者信息

Kim D W, Bang K H, Rhee Y H, Lee K T, Park H J

机构信息

Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Arch Pharm Res. 1998 Dec;21(6):688-91. doi: 10.1007/BF02976758.

DOI:10.1007/BF02976758

PMID:9868538

Abstract

Antifungal activities of the compounds isolated from Kalopanax pictus against representative fungi of dermatomycosis were investigated using paper disc diffusion method. It was found that kalopanaxsaponins A and I were effective in inhibiting the growth of Candida albicans KCTC 1940 and Cryptococcus neoformans KCTC 7224 with minimum inhibitory concentration (MIC) of 25 micrograms/ml. It showed that antifungal activity of both compounds have strong selectivity against the fungi of dermatomycosis.

摘要

采用纸片扩散法研究了从刺楸中分离出的化合物对皮肤真菌代表性菌株的抗真菌活性。结果发现，刺楸皂苷A和I对白色念珠菌KCTC 1940和新生隐球菌KCTC 7224的生长具有抑制作用，最低抑菌浓度（MIC）为25微克/毫升。这表明这两种化合物的抗真菌活性对皮肤真菌具有很强的选择性。