Barnes C S, Brigell M G, Alexander K R
Department of Neurology, and the Neuroscience and Aging Institute, Loyola University Chicago, Maywood, Illinois 60153, USA.
Retina. 1998;18(6):531-8. doi: 10.1097/00006982-199811000-00007.
To investigate possible functional correlates of an apparent ON-pathway defect observed in the cone electroretinogram of a patient with acquired unilateral night blindness.
Visual evoked potentials were recorded to the onset of a grid pattern consisting of either incremental or decremental squares. Saccadic eye movements were measured to luminance increments and decrements presented 5 degrees from fixation. The patient's results were compared with normative data.
Visual evoked potential latencies were prolonged to incremental stimulation of the patient's affected left eye but were within normal limits for the other three conditions (increments and decrements, right eye; decrements, left eye). A similar pattern of asymmetry between latencies to incremental and decremental stimulation of the affected eye was observed for saccadic eye movements.
The observed predominant delay in response to luminance increments supports the hypothesis of an ON-pathway dysfunction in this patient with acquired unilateral night blindness.
研究一名获得性单侧夜盲症患者视锥细胞视网膜电图中观察到的明显视锥通路缺陷可能存在的功能相关性。
记录对由递增或递减方块组成的网格图案起始部分的视觉诱发电位。测量对在注视点偏离5度处呈现的亮度增加和减少时的扫视眼动。将患者的结果与正常数据进行比较。
对患者受影响的左眼进行递增刺激时，视觉诱发电位潜伏期延长，但在其他三种情况（右眼的递增和递减；左眼的递减）下均在正常范围内。对于扫视眼动，在受影响眼对递增和递减刺激的潜伏期之间也观察到类似的不对称模式。
观察到的对亮度增加反应的主要延迟支持了该获得性单侧夜盲症患者存在视锥通路功能障碍的假设。
