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In vitro activities of voriconazole, fluconazole, and itraconazole against 566 clinical isolates of Cryptococcus neoformans from the United States and Africa.伏立康唑、氟康唑和伊曲康唑对来自美国和非洲的566株新生隐球菌临床分离株的体外活性。
Antimicrob Agents Chemother. 1999 Jan;43(1):169-71. doi: 10.1128/AAC.43.1.169.
2
In vitro comparative efficacy of voriconazole and itraconazole against fluconazole-susceptible and -resistant Cryptococcus neoformans isolates.伏立康唑和伊曲康唑对氟康唑敏感及耐药新生隐球菌分离株的体外比较疗效
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3
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本文引用的文献

1
In vitro comparative efficacy of voriconazole and itraconazole against fluconazole-susceptible and -resistant Cryptococcus neoformans isolates.伏立康唑和伊曲康唑对氟康唑敏感及耐药新生隐球菌分离株的体外比较疗效
Antimicrob Agents Chemother. 1998 Feb;42(2):471-2. doi: 10.1128/AAC.42.2.471.
2
Cryptococcal meningitis in human immunodeficiency virus-infected patients in Harare, Zimbabwe.
Clin Infect Dis. 1998 Feb;26(2):284-9. doi: 10.1086/516298.
3
The hidden danger of primary fluconazole prophylaxis for patients with AIDS.艾滋病患者氟康唑初级预防的隐患。
Clin Infect Dis. 1998 Jan;26(1):186-7. doi: 10.1086/517056.
4
In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp.伏立康唑（UK-109,496）及其他四种抗真菌药物对394株念珠菌属临床分离株的体外活性
Antimicrob Agents Chemother. 1998 Jan;42(1):161-3. doi: 10.1128/AAC.42.1.161.
5
In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens.新型三唑类药物伏立康唑（UK-109,496）对机会性丝状真菌和双相真菌以及常见和新出现的酵母病原体的体外活性。
J Clin Microbiol. 1998 Jan;36(1):198-202. doi: 10.1128/JCM.36.1.198-202.1998.
6
Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species.伏立康唑（UK-109,496）可抑制氟康唑敏感及耐药念珠菌属的生长并改变其形态。
Antimicrob Agents Chemother. 1997 Aug;41(8):1840-2. doi: 10.1128/AAC.41.8.1840.
7
In vitro evaluation of voriconazole against some clinically important fungi.伏立康唑对某些临床重要真菌的体外评价。
Antimicrob Agents Chemother. 1997 Aug;41(8):1832-4. doi: 10.1128/AAC.41.8.1832.
8
Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Mycoses Study Group and AIDS Clinical Trials Group.获得性免疫缺陷综合征相关隐球菌性脑膜炎的治疗。美国国立过敏和传染病研究所真菌病研究组及艾滋病临床试验组。
N Engl J Med. 1997 Jul 3;337(1):15-21. doi: 10.1056/NEJM199707033370103.
9
Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and candida infections. Subcommittee on Antifungal Susceptibility Testing of the National Committee for Clinical Laboratory Standards.抗真菌药敏试验解释性断点的制定：氟康唑、伊曲康唑和念珠菌感染的体外-体内相关性数据的概念框架与分析。美国国家临床实验室标准委员会抗真菌药敏试验小组委员会
Clin Infect Dis. 1997 Feb;24(2):235-47. doi: 10.1093/clinids/24.2.235.
10
In vitro studies of activity of voriconazole (UK-109,496), a new triazole antifungal agent, against emerging and less-common mold pathogens.新型三唑类抗真菌药物伏立康唑（UK-109,496）对新出现的及较少见霉菌病原体活性的体外研究。
Antimicrob Agents Chemother. 1997 Apr;41(4):841-3. doi: 10.1128/AAC.41.4.841.

伏立康唑、氟康唑和伊曲康唑对来自美国和非洲的566株新生隐球菌临床分离株的体外活性。

In vitro activities of voriconazole, fluconazole, and itraconazole against 566 clinical isolates of Cryptococcus neoformans from the United States and Africa.

作者信息

Pfaller M A, Zhang J, Messer S A, Brandt M E, Hajjeh R A, Jessup C J, Tumberland M, Mbidde E K, Ghannoum M A

机构信息

Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.

出版信息

Antimicrob Agents Chemother. 1999 Jan;43(1):169-71. doi: 10.1128/AAC.43.1.169.

DOI:10.1128/AAC.43.1.169
PMID:9869586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89041/
Abstract

We investigated the in vitro activity of voriconazole compared to those of fluconazole and itraconazole against 566 clinical isolates of Cryptococcus neoformans from Africa (164) and the United States (402). Isolates were obtained from cerebrospinal fluid (362), blood (139), and miscellaneous sites (65). Voriconazole (MIC at which 90% of the isolates are inhibited [MIC90], 0.12 to 0.25 microg/ml) was more active than either itraconazole (MIC90, 0.5 microg/ml) or fluconazole (MIC90, 8.0 to 16 microg/ml) against both African and U. S. isolates. Isolates inhibited by >/=16 microg of fluconazole per ml were almost all (99%) inhibited by </=1 microg of voriconazole per ml. These results suggest that voriconazole may be useful in the treatment of cryptococcosis.

摘要

我们研究了伏立康唑与氟康唑和伊曲康唑相比，对来自非洲（164株）和美国（402株）的566株新生隐球菌临床分离株的体外活性。分离株取自脑脊液（362株）、血液（139株）和其他部位（65株）。伏立康唑（对90%分离株产生抑制作用的最低抑菌浓度[MIC90]为0.12至0.25微克/毫升）对非洲和美国的分离株的活性均高于伊曲康唑（MIC90为0.5微克/毫升）或氟康唑（MIC90为8.0至16微克/毫升）。每毫升氟康唑抑制浓度≥16微克的分离株几乎全部（99%）被每毫升伏立康唑抑制浓度≤1微克所抑制。这些结果表明伏立康唑可能对治疗隐球菌病有用。