婴儿利什曼原虫引起的内脏利什曼病二线口服治疗的实验评估
Experimental evaluation of second-line oral treatments of visceral leishmaniasis caused by Leishmania infantum.
作者信息
Gangneux J P, Dullin M, Sulahian A, Garin Y J, Derouin F
机构信息
Laboratoire de Parasitologie-Mycologie, Faculté de Médecine Lariboisière-Saint-Louis, Paris, France.
出版信息
Antimicrob Agents Chemother. 1999 Jan;43(1):172-4. doi: 10.1128/AAC.43.1.172.
Abstract
In a murine model of Leishmania infantum visceral leishmaniasis, metronidazole, ketoconazole, fluconazole, itraconazole, and terbinafine were less effective than antimonial agents in reducing hepatic parasite load. Ketoconazole potentiated the effect of meglumine antimoniate reference therapy through its marked activity against spleen infection.
摘要
在婴儿利什曼原虫内脏利什曼病的小鼠模型中，甲硝唑、酮康唑、氟康唑、伊曲康唑和特比萘芬在降低肝脏寄生虫负荷方面比锑剂效果差。酮康唑通过其对脾脏感染的显著活性增强了葡甲胺锑酸盐参考疗法的效果。
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