痕迹基因（Vestigial）和扇贝基因（Scalloped）之间的分子相互作用促进果蝇翅膀的形成。
Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila.
作者信息
Simmonds A J, Liu X, Soanes K H, Krause H M, Irvine K D, Bell J B
机构信息
Banting and Best Department of Medical Research, Charles H. Best Institute, University of Toronto, Ontario M5G 1L6, Canada.
出版信息
Genes Dev. 1998 Dec 15;12(24):3815-20. doi: 10.1101/gad.12.24.3815.
Abstract
Scalloped (Sd) and Vestigial (Vg) are each needed for Drosophila wing development. We show that Sd is required for Vg function and that altering their relative cellular levels inhibits wing formation. In vitro, Vg binds directly to both Sd and its human homolog, Transcription Enhancer Factor-1. The interaction domains map to a small region of Vg that is essential for Vg-mediated gene activation and to the carboxy-terminal half of Sd. Our observations indicate that Vg and Sd function coordinately to control the expression of genes required for wing development, which implies that Vg is a tissue-specific transcriptional intermediary factor of Sd.
摘要
扇形（Sd）和痕迹（Vg）对于果蝇翅膀发育均是必需的。我们发现Sd是Vg发挥功能所必需的，并且改变它们的相对细胞水平会抑制翅膀形成。在体外，Vg直接与Sd及其人类同源物转录增强因子-1结合。相互作用结构域定位于Vg的一个小区域，该区域对于Vg介导的基因激活至关重要，并且定位于Sd的羧基末端一半区域。我们的观察结果表明，Vg和Sd协同发挥作用以控制翅膀发育所需基因的表达，这意味着Vg是Sd的组织特异性转录中间因子。
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本文引用的文献
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The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila.痕迹蛋白和扇形蛋白共同作用，直接调控果蝇翅膀特异性基因的表达。
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