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松解左右纤维三角以缓解严重的左心室流出道梗阻。

Mobilization of the left and right fibrous trigones for relief of severe left ventricular outflow obstruction.

作者信息

Yacoub M, Onuzo O, Riedel B, Radley-Smith R

机构信息

Department of Cardiothoracic Surgery, Royal Brompton and Harefield Hospital, Imperial College of Science, Medicine and Technology, Heart Science Center, Harefield, Uxbridge, Middlesex, United Kingdom.

出版信息

J Thorac Cardiovasc Surg. 1999 Jan;117(1):126-32; discussion 32-3. doi: 10.1016/s0022-5223(99)70477-0.

Abstract

BACKGROUND

There is still no agreement about the optimal method of surgical relief of fixed subaortic stenosis, particularly the severe forms.

OBJECTIVES

The purpose of this study was to describe a new technique for the relief of subaortic stenosis based on analysis of the functional anatomy of the left ventricular outflow tract and pathophysiologic features of subaortic stenosis.

METHODS AND PATIENTS

We propose that one of the basic abnormalities in subaortic stenosis is interference with the hinge mechanism provided by the 2 fibrous trigones with progressive deposition of fibrous tissue in these angles. The technique described in this paper consists of excision of all components of the fibrous "ring," with mobilization of the left and right fibrous trigones. This results in the restoration of the normal dynamic behavior of the left ventricular outflow tract with maximal widening of the outflow tract as the result of backward displacement of the subaortic curtain and anterior leaflet of the mitral valve. This technique has been used in 57 consecutive patients who ranged in age between 5 months and 56 years (mean, 15.5 +/- 10.6 years). Gradients across the left ventricular outflow tract were between 45 and 200 mm Hg (mean, 86.7 mm Hg). Additional lesions were present in 10 patients, and 7 patients had had 8 previous operations on the left ventricular outflow tract. At operation, in addition to resection of subaortic stenosis, 3 patients had aortic valvotomy, 2 patients had homograft replacement of the aortic valve, 7 patients had patch closure of a ventricular septal defect, and 1 patient had open mitral valvotomy.

RESULTS

There were 2 early deaths and 1 late sudden death during the follow-up period that ranged from 1 month to 25 years (mean, 15. 2 years). One patient experienced the development of endocarditis on the aortic valve 7 years after operation, which was successfully treated by homograft replacement. Postoperative gradients across the left ventricular outflow tract varied from no gradient to 30 mm Hg (mean, 8 mm Hg). There were no instances of recurrence of a gradient across the left ventricular outflow tract.

CONCLUSION

It is concluded that mobilization of the left and right fibrous trigones results in durable relief of subaortic stenosis.

摘要

背景

对于固定性主动脉瓣下狭窄,尤其是严重形式的最佳手术缓解方法仍未达成共识。

目的

本研究的目的是基于对左心室流出道功能解剖和主动脉瓣下狭窄病理生理特征的分析,描述一种缓解主动脉瓣下狭窄的新技术。

方法与患者

我们提出主动脉瓣下狭窄的基本异常之一是两个纤维三角提供的铰链机制受到干扰,这些角度处有纤维组织逐渐沉积。本文所述技术包括切除纤维“环”的所有成分,并游离左右纤维三角。这导致左心室流出道恢复正常动态行为,由于主动脉瓣下帘和二尖瓣前叶向后移位,流出道得以最大程度地增宽。该技术已应用于57例连续患者,年龄在5个月至56岁之间(平均15.5±10.6岁)。左心室流出道的压差在45至200mmHg之间(平均86.7mmHg)。10例患者存在其他病变,7例患者此前对左心室流出道进行过8次手术。手术时,除了切除主动脉瓣下狭窄外,3例患者进行了主动脉瓣切开术,2例患者进行了同种异体主动脉瓣置换术,7例患者进行了室间隔缺损补片修补术,1例患者进行了二尖瓣直视切开术。

结果

在1个月至25年(平均15.2年)的随访期内,有2例早期死亡和1例晚期猝死。1例患者术后7年发生主动脉瓣心内膜炎,通过同种异体瓣膜置换成功治疗。术后左心室流出道的压差从无压差到30mmHg不等(平均8mmHg)。没有左心室流出道压差复发的情况。

结论

得出结论,游离左右纤维三角可持久缓解主动脉瓣下狭窄。

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