通过微囊化大鼠胰岛异种移植逆转链脲佐菌素诱导的糖尿病小鼠的高血糖症
Reversal of hyperglycemia in streptozotocin diabetic mice by xenotransplantation of microencapsulated rat islets.
作者信息
Tatarkiewicz K, Sitarek E, Sabat M, Orłowski T
机构信息
Institute of Biocybernetics & Biomedical Engineering, Warsaw, Poland.
出版信息
Ann Transplant. 1997;2(2):20-3.
Rat pancreatic islets were immunoisolated within alginate capsules with additional polyethyleneimine-protamine-heparin highly biocompatible membrane. Perifusion study in vitro demonstrated satisfactory similarities between the insulin release profiles of encapsulated and free islets. Concordant xenotransplantation of microencapsulated rat islets significantly prolonged mean time of restored normoglycemia (46 +/- 15 days) in streptozotocin-diabetic BALB/c mice recipients comparing to uncoated grafts (7 +/- 2 days).
大鼠胰岛在含有额外聚乙烯亚胺-鱼精蛋白-肝素高生物相容性膜的藻酸盐胶囊内进行免疫隔离。体外灌流研究表明，包封胰岛和游离胰岛的胰岛素释放曲线具有令人满意的相似性。与未包被的移植物（7±2天）相比，微囊化大鼠胰岛的协同异种移植显著延长了链脲佐菌素诱导的糖尿病BALB/c小鼠受体恢复正常血糖的平均时间（46±15天）。
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