Eluri R, Paul C, Roemer R, Boyko O
Neuroscience Research Group, Department of Psychiatry and Behavioral Science, Temple University Health Sciences Center, Philadelphia, PA 19140, USA.
Psychiatry Res. 1998 Nov 9;84(1):17-26. doi: 10.1016/s0925-4927(98)00043-2.
Magnetic resonance spectroscopy (MRS) is a non-invasive functional imaging technique that can measure various brain tissue metabolites such as N-acetylaspartate (NAA), choline (Cho), creatine-phosphocreatine (Cr), myo-inositol (mI) and other metabolites. Morphological studies have indicated the pons and cerebellum as possible sites of abnormal functioning in schizophrenic patients. This study examines schizophrenic patients for the presence of abnormalities in proton MRS (1H-MRS) measured metabolites in two regions of the posterior fossa. Twelve schizophrenic patients and eight non-schizophrenic control subjects were studied by measuring the ratios of NAA/Cr, Cho/Cr and mI/Cr from 1H-spectra obtained from the pons and right or left cerebellum using an integrated MRI/MRS protocol. Spectra were obtained from a voxel in the pons and voxels from the left and/or right lateral cerebellum. Data were analyzed in the absorption mode and fitted to Lorentzian lineshapes using a Marquart algorithm. Significantly lower NAA/Cr ratios were found in the pons of schizophrenic patients than in the control subjects, but not in the cerebellum. This study is the first to measure brain tissue metabolites using 1H-MRS in the pons and cerebellum of schizophrenic patients. Significant alterations of 1H-MRS metabolites may suggest the involvement of the posterior fossa as a part of the pathological substrate underlying schizophrenia.
磁共振波谱（MRS）是一种非侵入性的功能成像技术，可测量各种脑组织代谢物，如N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸-磷酸肌酸（Cr）、肌醇（mI）和其他代谢物。形态学研究表明，脑桥和小脑可能是精神分裂症患者功能异常的部位。本研究通过检测后颅窝两个区域质子磁共振波谱（1H-MRS）测量的代谢物中是否存在异常，对精神分裂症患者进行了检查。通过使用集成的MRI/MRS协议，从脑桥以及右侧或左侧小脑获得的1H谱中测量NAA/Cr、Cho/Cr和mI/Cr的比率，对12名精神分裂症患者和8名非精神分裂症对照受试者进行了研究。谱图是从脑桥中的一个体素以及左侧和/或右侧小脑的体素中获得的。数据在吸收模式下进行分析，并使用Marquart算法拟合为洛伦兹线形。在精神分裂症患者的脑桥中发现NAA/Cr比率显著低于对照受试者，但在小脑中未发现。本研究首次在精神分裂症患者的脑桥和小脑中使用1H-MRS测量脑组织代谢物。1H-MRS代谢物的显著改变可能表明后颅窝作为精神分裂症潜在病理基质的一部分参与其中。
