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整合宿主因子（IHF）影响大肠杆菌中磷酸结合蛋白和碱性磷酸酶的表达。

The integration host factor (IHF) affects the expression of the phosphate-binding protein and of alkaline phosphatase in Escherichia coli.

作者信息

Spira B, Yagil E

机构信息

Department of Biochemistry, Tel-Aviv University, Israel.

出版信息

Curr Microbiol. 1999 Feb;38(2):80-5. doi: 10.1007/s002849900407.

DOI:10.1007/s002849900407
PMID:9871104
Abstract

The genes encoding alkaline phosphatase (phoA) and the inducible inorganic phosphate transport system Pst (pstS,C,A,B,U) belong to the PHO regulon. Mutants of Escherichia coli lacking the global regulatory protein integration host factor (IHF) show an increased level of alkaline phosphatase and a decreased level of Pst. IHF binds weakly but specifically to a DNA fragment containing the promoter region of the pst operon but does not bind to a fragment that includes the promoter region of phoA. It is proposed that IHF is a positive regulator of the pst operon and as such controls indirectly the expression of phoA.

摘要

编码碱性磷酸酶（phoA）的基因以及可诱导的无机磷酸盐转运系统Pst（pstS、C、A、B、U）属于PHO调节子。缺乏全局调节蛋白整合宿主因子（IHF）的大肠杆菌突变体显示碱性磷酸酶水平升高，而Pst水平降低。IHF与包含pst操纵子启动子区域的DNA片段弱但特异性结合，但不与包含phoA启动子区域的片段结合。有人提出，IHF是pst操纵子的正调节因子，因此间接控制phoA的表达。

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