关于重组β(1-3)半乳糖基转移酶的制备应用。
On the preparative use of recombinant beta(1-3)galactosyl-transferase.
作者信息
Baisch G, Ohrlein R, Streiff M, Kolbinger F
机构信息
Novartis Pharma AG, Schwarzwaldallee, Basle, Switzerland.
出版信息
Bioorg Med Chem Lett. 1998 Apr 7;8(7):751-4. doi: 10.1016/s0960-894x(98)00093-6.
PMID:9871535
Abstract
A number of non-natural N-acyl derivatives of glucosamine is incubated with a recombinant beta(1-3)galactosyl-transferase and UDP-galactose. Surprisingly, the enzyme recognizes the non-natural acceptors as substrates and transfers galactose onto the 3-OH group in a beta-mode to give a series of Lewis(c)-(type 1) disaccharides.
摘要
将多种非天然的氨基葡萄糖N-酰基衍生物与重组β(1-3)半乳糖基转移酶和UDP-半乳糖一起孵育。令人惊讶的是，该酶将这些非天然受体识别为底物，并以β模式将半乳糖转移到3-OH基团上，生成一系列Lewis(c)-(1型)二糖。
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