Furumi K, Fujioka T, Fujii H, Okabe H, Nakano Y, Matsunaga H, Katano M, Mori M, Mihashi K
Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Bioorg Med Chem Lett. 1998 Jan 6;8(1):93-6. doi: 10.1016/s0960-894x(97)10193-7.
Four novel antiproliferative furanocoumarin ethers of falcarindiol, named japoangelols A (8.5), B (7.2), C (7.4), and D (8.4), were isolated from the root of Angelica japonica together with panaxynol (0.3), falcarindiol (3.2), (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2.2), and 8-acetoxyfalcarinol (3.2). Structures were established from the spectroscopic evidence, and the inhibitory activities (ED50, microgram/ml, shown in the parentheses) were evaluated using the MTT assay.
从日本当归根部分离出四种新的法卡林二醇抗增殖呋喃香豆素醚，命名为日本当归醇A（8.5）、B（7.2）、C（7.4）和D（8.4），同时还分离出了人参炔醇（0.3）、法卡林二醇（3.2）、（9Z）-1,9-十七碳二烯-4,6-二炔-3,8,11-三醇（2.2）和8-乙酰氧基法卡林醇（3.2）。通过光谱证据确定了结构，并使用MTT法评估了抑制活性（括号内显示的ED50，微克/毫升）。
