伞形科植物的抗增殖成分。V. 来自当归根的一种新呋喃香豆素和镰叶芹二醇呋喃香豆素醚

Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica.

作者信息

Fujioka T, Furumi K, Fujii H, Okabe H, Mihashi K, Nakano Y, Matsunaga H, Katano M, Mori M

机构信息

Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1999 Jan;47(1):96-100. doi: 10.1248/cpb.47.96.

DOI:10.1248/cpb.47.96

PMID:9987830

Abstract

The CHCl3 extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone and four furanocoumarin ethers of falcarindiol, named japoangelols A-D, were isolated together with caffeic acid methyl ester, four polyacetylenic compounds (panaxynol, falcarindiol, 8-O-acetylfalcarindiol, and (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol), eight coumarins (osthol, isoimperatorin, scopoletin, byakangelicin, xanthotoxin, bergapten, oxypeucedanin methanolate, and oxypeucedanin hydrate), and two chromones (3'-O-acetylhamaudol, and hamaudol). The structures of the new isolates were determined based on spectral evidence. The ED50 of isolates against MK-1, HeLa, and B16F10 cell lines are reported.

摘要

日本当归根的氯仿提取物对人胃腺癌（MK-1）细胞生长显示出高抑制活性。从该提取物中，分离出一种名为日本当归酮的新呋喃香豆素和四种法卡林二醇的呋喃香豆素醚，分别命名为日本当归醇A-D，同时还分离出咖啡酸甲酯、四种聚乙炔化合物（人参炔醇、法卡林二醇、8-O-乙酰法卡林二醇和(9Z)-1,9-十七碳二烯-4,6-二炔-3,8,11-三醇）、八种香豆素（蛇床子素、异欧前胡素、东莨菪素、白芷当归素、花椒毒素、补骨脂素、氧化前胡素甲醇化物和氧化前胡素水合物）以及两种色酮（3'-O-乙酰哈马豆醇和哈马豆醇）。新分离物的结构基于光谱证据确定。报道了分离物对MK-1、HeLa和B16F10细胞系的半数有效剂量（ED50）。