用重组岩藻糖基转移酶III对非天然唾液酸化I型三糖进行酶促岩藻糖基化反应。
Enzymatic fucosylations of non-natural sialylated type-I trisaccharides with recombinant fucosyl-transferase-III.
作者信息
Baisch G, Ohrlein R, Streiff M
机构信息
Novartis Pharma AG, Basle, Switzerland.
出版信息
Bioorg Med Chem Lett. 1998 Jan 20;8(2):161-4. doi: 10.1016/s0960-894x(97)10202-5.
PMID:9871646
Abstract
Recombinant fucosyl-transferase-III (Lewis type enzyme) is used to prepare a series of non-natural sialyl-Lewis derivatives on a preparative scale. The enzyme tolerates a wide range of acceptors which have the natural N-acetyl group of the glucosamine moiety replaced by substituted aromatic and heteroaromatic amides.
摘要
重组岩藻糖基转移酶III（Lewis型酶）用于在制备规模上制备一系列非天然唾液酸-Lewis衍生物。该酶能耐受多种受体，这些受体的葡糖胺部分的天然N-乙酰基被取代的芳香族和杂芳香族酰胺所取代。
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