具有两个非天然单糖单元的唾液酸-Lewis(a)文库的酶促合成。
Enzymatic synthesis of sialyl-Lewis(a)-libraries with two non-natural monosaccharide units.
作者信息
Baisch G, Ohrlein R, Streiff M, Kolbinger F
机构信息
Novartis Pharma AG, Schwarzwaldallee, Basle, Switzerland.
出版信息
Bioorg Med Chem Lett. 1998 Apr 7;8(7):755-8. doi: 10.1016/s0960-894x(98)00092-4.
PMID:9871536
Abstract
A series of sialylated type-I sugars, which have the natural N-acetyl group of the glucosamine moiety replaced by a wide range of amides, is incubated with recombinant fucosyl-transferase III and non-natural guanosine-diphosphate activated donor-sugars. Surprisingly, the enzyme tolerates the simultaneous alterations on the donor and acceptor to form a wide array of sialyl-Lewis(a)-analogues.
摘要
一系列唾液酸化的I型糖，其葡糖胺部分的天然N-乙酰基被多种酰胺取代，与重组岩藻糖基转移酶III和非天然鸟苷二磷酸活化的供体糖一起孵育。令人惊讶的是，该酶能够耐受供体和受体上的同时改变，从而形成多种唾液酸化路易斯（a）类似物。
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