用重组唾液酸转移酶对非天然I型（Lewis）二糖进行酶促α(2-3)唾液酸化。
Enzymatic alpha(2-3)sialylation of non-natural type-I (Lewisc) disaccharides with recombinant sialyl-transferase.
作者信息
Baisch G, Ohrlein R, Streiff M
机构信息
Novartis Pharma AG, Basle, Switzerland.
出版信息
Bioorg Med Chem Lett. 1998 Jan 20;8(2):157-60. doi: 10.1016/s0960-894x(97)10201-3.
PMID:9871645
Abstract
Recombinant alpha(2-3)sialyl-transferase from rat liver is used to sialylate a series of type-I (Lewisc) disaccharides on a preparative scale. The enzyme tolerates a broad array of N-acetyl replacements of the N-glucosamine subunit ranging from small and large lipophilic groups to charged and heterocyclic amides.
摘要
来自大鼠肝脏的重组α(2-3)唾液酸转移酶被用于大规模唾液酸化一系列I型（Lewis）二糖。该酶能耐受N-乙酰葡糖胺亚基的多种N-乙酰取代基，范围从小的和大的亲脂性基团到带电荷的和杂环酰胺。
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