Quaternary substituted PDE4 inhibitors I: the synthesis and in vitro evaluation of a novel series of oxindoles.
作者信息
Hulme C, Poli G B, Huang F C, Souness J E, Djuric S W
机构信息
Rhône-Poulenc Rorer Central Research, Collegeville, PA 19426, USA.
出版信息
Bioorg Med Chem Lett. 1998 Jan 20;8(2):175-8. doi: 10.1016/s0960-894x(97)10206-2.
PMID:9871649
Abstract
The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constrained analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with sub-micromolar IC50's for PDE4 inhibition are reported.
摘要
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