Vaccaro W D, Davis H R
Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.
Bioorg Med Chem Lett. 1998 Feb 3;8(3):313-8. doi: 10.1016/s0960-894x(98)00008-0.
A glucuronide conjugate of the potent 2-azetidinone cholesterol absorption inhibitor Sch 58235 was synthesized to confirm the structure of a metabolite isolated from in vivo sources. A series of 2-azetidinone glycosides was prepared via Schmidt trichloroimidate methodology. Enhanced cholesterol absorption inhibition was achieved by modification of the sugar moiety.
