蛋白酶体的强效和选择性抑制剂：二肽基硼酸
Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids.
作者信息
Adams J, Behnke M, Chen S, Cruickshank A A, Dick L R, Grenier L, Klunder J M, Ma Y T, Plamondon L, Stein R L
机构信息
ProScript, Inc., Cambridge, MA 02139, USA.
出版信息
Bioorg Med Chem Lett. 1998 Feb 17;8(4):333-8. doi: 10.1016/s0960-894x(98)00029-8.
PMID:9871680
Abstract
Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such as 15 are promising new therapeutics for treatment of cancer and inflammatory diseases.
摘要
本文描述了强效且具有选择性的二肽基硼酸蛋白酶体抑制剂。与肽醛化合物相比，该系列中的硼酸显示出显著增强的效力。诸如化合物15等有望成为治疗癌症和炎症性疾病的新型治疗药物。
Zotero 插件