3-三氟甲基碳头孢烯类：广谱抗菌化合物的合成
3-trifluoromethylcarbacephems: synthesis of broad spectrum antibacterial compounds.
作者信息
Cook G K, Hornback W J, McDonald J H, Munroe J E, Snyder N J
机构信息
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
出版信息
Bioorg Med Chem Lett. 1998 May 19;8(10):1261-6. doi: 10.1016/s0960-894x(98)00204-2.
PMID:9871746
Abstract
The enhanced stability of the carbacephem nucleus over the corresponding cephalosporin nucleus has allowed the synthesis of 7-arylglycyl-3-trifluoromethyl-carbacephems. These unique carbacephems possess broad spectrum activity and high stability to both plasmid and chromosomally mediated beta-lactamases.
摘要
碳头孢烯核相对于相应头孢菌素核具有更高的稳定性，这使得7-芳基甘氨酰-3-三氟甲基碳头孢烯得以合成。这些独特的碳头孢烯具有广谱活性，对质粒介导和染色体介导的β-内酰胺酶均具有高稳定性。
Zotero 插件