Knothe H
Infection. 1979;7 Suppl 6:518-26. doi: 10.1007/BF01659726.
A comparative study was conducted on the in vitro activity of cefaclor and other oral cephalosporins against a large number of freshly isolated clinical strains of gram-negative and gram-positive bacteria. The activity of cefaclor against gram-positive pathogens is very similar to that of cephalexin. The action of cefaclor against Streptococcus pneumoniae is superior. Cefaclor is the most active antibiotic against strains of Haemophilus influenzae, and is also more active than cephalexin and cephradine against non-beta-lactamase producing strains of Escherichia coli, Klebsiella species and Proteus mirabilis.
对头孢克洛和其他口服头孢菌素针对大量新分离的革兰氏阴性和革兰氏阳性细菌临床菌株的体外活性进行了一项比较研究。头孢克洛对革兰氏阳性病原体的活性与头孢氨苄非常相似。头孢克洛对肺炎链球菌的作用更优。头孢克洛是针对流感嗜血杆菌菌株最具活性的抗生素,并且在针对非产β-内酰胺酶的大肠杆菌、克雷伯菌属和奇异变形杆菌菌株方面也比头孢氨苄和头孢拉定更具活性。