Zervas I M, Pehlivanidis A A, Papakostas Y G, Markianos M, Papadimitriou G N, Stefanis C N
Department of Psychiatry, Athens University Medical School, Eginition Hospital, Greece.
J ECT. 1998 Dec;14(4):236-40.
We investigated the effect of thyrotropin-releasing hormone (TRH) on orientation time and recall, in nine depressed female inpatients undergoing electroconvulsive therapy (ECT). In a balanced order crossover design, an intravenous bolus of 0.4 mg TRH or placebo was administered 20 min before ECT in the first two sessions. Orientation time and retrograde and anterograde components of the memory dysfunction, immediately and 24 h later, were assessed. Administration of TRH did not influence orientation time, word recall, or immediate short story recall compared with placebo. We did find, however, an improvement in the number of short story items recalled after 24 h when patients were given TRH compared with placebo. This indicates that TRH may have a protective role against the specific negative effect of ECT on delayed recall.
我们对9名接受电休克治疗（ECT）的抑郁症女性住院患者，研究了促甲状腺激素释放激素（TRH）对定向时间和记忆的影响。在前两个疗程中，采用平衡顺序交叉设计，在ECT前20分钟静脉推注0.4mg TRH或安慰剂。在ECT后即刻及24小时后，评估定向时间以及记忆功能障碍的逆行和顺行成分。与安慰剂相比，TRH的给药并未影响定向时间、单词记忆或即刻短篇小说记忆。然而，我们确实发现，与安慰剂相比，患者接受TRH治疗后24小时回忆起的短篇小说项目数量有所改善。这表明TRH可能对ECT对延迟记忆的特定负面影响具有保护作用。
