Hamze M, Naboulsi M, Vincent P
Université Libanaise, Faculté de Santé Publique, Tripoli, Liban.
Pathol Biol (Paris). 1998 Oct;46(8):613-6.
Typhoid fever is a major public health problem in developing countries. In Lebanon, where the sanitary infrastructure was severely damaged during the civil war, the high prevalence of typhoid fever creates a pressing need for a rapid and reliable diagnostic tool. To evaluate the diagnostic usefulness of the Widal test, patients with a positive blood culture for Salmonella typhi (n = 78) were compared to controls with fever due to another infection (n = 65) and with blood donors (n = 96). Discrimination between the patient group and the two control groups was best when an agglutinin O titer of 1/160 or more was used. With this cutoff, sensitivity was 67.9%; specificity was 93.8% versus the febrile controls and 100% versus the blood donors. These results suggest that despite its well-known limitations the Widal test remains a valuable tool for typhoid fever control in many developing countries.
伤寒热是发展中国家的一个主要公共卫生问题。在黎巴嫩,其卫生基础设施在内战期间遭到严重破坏,伤寒热的高发病率使得迫切需要一种快速可靠的诊断工具。为评估肥达氏试验的诊断效用,将伤寒沙门氏菌血培养呈阳性的患者(n = 78)与因其他感染而发热的对照组(n = 65)以及献血者(n = 96)进行了比较。当使用1/160或更高的凝集素O滴度时,患者组与两个对照组之间的区分效果最佳。以此为临界值,对发热对照组的敏感性为67.9%;特异性为93.8%,对献血者的特异性为100%。这些结果表明,尽管肥达氏试验存在众所周知的局限性,但在许多发展中国家,它仍然是控制伤寒热的一种有价值的工具。