杵状指与肺癌
Digital clubbing and lung cancer.
作者信息
Sridhar K S, Lobo C F, Altman R D
机构信息
Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, FL 33136, USA.
出版信息
Chest. 1998 Dec;114(6):1535-7. doi: 10.1378/chest.114.6.1535.
OBJECTIVES
To determine the relative frequency of clubbing in small cell lung carcinoma (SCLC) versus non-small cell lung carcinoma (NSCLC).
DESIGN
Examine patients with lung cancer for digital clubbing and relate the findings to the histopathologic subtype of lung cancer.
SETTING
Cancer center at a tertiary teaching hospital.
PATIENTS OR PARTICIPANTS
One hundred and eleven consecutive patients with a pathological diagnosis of lung cancer examined by one physician (KSS).
INTERVENTIONS
None.
MEASUREMENTS AND RESULTS
Clubbing was present in 32 (29%) of the 111 patients with lung cancer. Clubbing was more common in women (40%) than in men (19%; chi2 test p = 0.011), and was more common in patients with NSCLC (35%) than those with SCLC (4%; chi2 test p = 0.0036).
CONCLUSION
In a prospective study, digital clubbing was less frequently observed in men than women and in patients with SCLC than NSCLC. These clinical observations may assist in the initial evaluation of patients for planning workup and therapy.
目的
确定小细胞肺癌（SCLC）与非小细胞肺癌（NSCLC）中杵状指的相对发生率。
设计
检查肺癌患者是否有杵状指，并将结果与肺癌的组织病理学亚型相关联。
地点
一所三级教学医院的癌症中心。
患者或参与者
由一名医生（KSS）检查的111例经病理诊断为肺癌的连续患者。
干预措施
无。
测量与结果
111例肺癌患者中有32例（29%）出现杵状指。杵状指在女性（40%）中比男性（19%）更常见（卡方检验p = 0.011），在NSCLC患者（35%）中比SCLC患者（4%）更常见（卡方检验p = 0.0036）。
结论
在一项前瞻性研究中，男性和SCLC患者中观察到杵状指的频率低于女性和NSCLC患者。这些临床观察结果可能有助于对患者进行初步评估，以制定检查和治疗计划。
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