Sjöqvist U, Permert J, Löfberg R, Larsson J, Gadaleanu V, Adrian T E
Department of Gastroenterology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Eur J Gastroenterol Hepatol. 1998 Nov;10(11):963-7. doi: 10.1097/00042737-199811000-00011.
A 30-year-old previously healthy woman was diagnosed as having a vasoactive intestinal polypeptide (VIP)-producing tumour of the pancreas. Her medical history was typical for neuroendocrine gastrointestinal tumours, presenting initially with non-specific symptoms but eventually she developed life-threatening manifestations requiring intensive care due to severe dehydration. She immediately recovered following surgical resection. The patient had elevated serum concentrations of VIP as well as pancreastatin, and post-operatively elevated concentrations of three growth factors, IGF-I, EGF and TGF-alpha, were seen. The importance of the alterations in plasma concentrations of the different peptides for her symptomatology are discussed.
一名30岁既往健康的女性被诊断为患有产生血管活性肠肽（VIP）的胰腺肿瘤。她的病史符合神经内分泌性胃肠道肿瘤的典型表现，最初表现为非特异性症状，但最终因严重脱水出现危及生命的症状而需要重症监护。手术切除后她立即康复。该患者血清VIP以及胰抑制素浓度升高，术后还可见三种生长因子，即胰岛素样生长因子-I（IGF-I）、表皮生长因子（EGF）和转化生长因子-α（TGF-α）浓度升高。本文讨论了不同肽类血浆浓度变化对其症状学的重要性。
