一种将醛与固体支持物偶联的简单方法。
A simple method for coupling aldehydes to solid support.
作者信息
Metz W A, Jones W D, Ciske F L, Peet N P
机构信息
Hoechst Marion Roussel Inc., Cincinnati, Ohio 45215, USA.
出版信息
Bioorg Med Chem Lett. 1998 Sep 8;8(17):2399-402. doi: 10.1016/s0960-894x(98)00434-x.
PMID:9873549
Abstract
A new method for attaching aldehydes to solid supports has been developed employing a 2,2-bis(hydroxymethyl)propionic acid (DMPA) functionalized resin. High loading levels are obtained for both aryl and alkyl aldehydes protected as their respective acetals. Treatment of the derivatized resin with 95% TFA then cleanly affords the recovered aldehyde in high yield.
摘要
已开发出一种使用2,2-双(羟甲基)丙酸(DMPA)官能化树脂将醛连接到固体载体上的新方法。对于以各自缩醛形式保护的芳基醛和烷基醛，均获得了高负载量。然后用95%的三氟乙酸处理衍生化树脂，可高产率地干净地得到回收的醛。
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