Sakai N, Ni C, Bezrukov S M, Matile S
Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
Bioorg Med Chem Lett. 1998 Oct 6;8(19):2743-6. doi: 10.1016/s0960-894x(98)00481-8.
In this Letter, we describe the appearance of large, voltage-dependent currents in BLM induced by rigid rod-shaped polyols that function without charge and permanent dipole moment. The capacity of these symmetrical, nonpeptide models to form either short-living nanopores or small ion channels is shown to depend critically on the length of rigid-rod scaffold as well as the nature of the lateral side chains.
