First synthesis of alternating SATE-phosphotriester/phosphodiester prooligonucleotides on solid support.
作者信息
Tosquellas G, Bologna J C, Morvan F, Rayner B, Imbach J L
机构信息
Laboratoire de Chimie Bio-Organique, UMR 5625, Université de Montpellier II, France.
出版信息
Bioorg Med Chem Lett. 1998 Oct 20;8(20):2913-8. doi: 10.1016/s0960-894x(98)00518-6.
PMID:9873647
Abstract
Prooligonucleotides with alternating S-Acyl-ThioEthyl (SATE) phosphotriester and phosphodiester linkages or a gap were synthesized by elimination of cyanoethyl group with non-nucleophilic base DBU. Their half-lives in the presence of Pig Liver Esterases (PLE) and in total cell extract were determined.
摘要
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