Andersen C, Hole P
Department of Cardiothoracic Anaesthesia, Odense University Hospital, Denmark.
Clin J Pain. 1998 Dec;14(4):315-9. doi: 10.1097/00002508-199812000-00008.
The only way some patients with intractable angina pectoris can endure the daily pain is by using opiates. Epidural morphine or spinal cord stimulation (SCS) for out-patients is a possibility for this patient group. The aim of this study was to determine whether patients previously treated with epidural injections had more frequent electrode migration, higher stimulation needs, and less effect of SCS treatment.
A prospective, nonrandomized study with a 4-year follow-up period.
Department of Anaesthesia, Pain Section. A referral center in institutional practice. Ambulatory care.
The patient group comprised 53 patients; all had been treated daily with opiates. A total of 26 patients had epidural catheters for a mean time of 1 year before SCS. All patients had intractable angina pectoris. For these patients, further angioplasty or coronary bypass surgery was not technically possible. Even with maximal medication, it was impossible to cope with the patients' angina pectoris, and the only way the patients could endure the daily pain was by using opiates. Therefore, alternative therapies were considered to give these patients palliation.
SCS with epidural electrodes stimulating paresthesia in the area where angina is perceived.
Difference for the patients previously treated with epidural catheters in stimulation amplitude, frequency of electrode migration, and effect of SCS.
Stimulation demand (p = 0.09), frequency of electrode migrations (p = 0.46), and pain-reducing effect (p = 0.16) were not different for the group of patients previously treated with epidural catheters for longer periods (1-36 months).
SCS in patients previously treated with epidural catheters has an effect equal to that in other patients.
一些顽固性心绞痛患者忍受日常疼痛的唯一方法是使用阿片类药物。对于这类患者,门诊患者可选择硬膜外注射吗啡或脊髓刺激(SCS)。本研究的目的是确定先前接受硬膜外注射治疗的患者是否电极迁移更频繁、刺激需求更高以及SCS治疗效果更差。
一项为期4年随访期的前瞻性、非随机研究。
麻醉科疼痛科。机构实践中的转诊中心。门诊护理。
患者组包括53名患者;所有患者均每日接受阿片类药物治疗。共有26名患者在接受SCS治疗前平均1年时间内留置硬膜外导管。所有患者均患有顽固性心绞痛。对于这些患者,进一步的血管成形术或冠状动脉搭桥手术在技术上不可行。即使使用最大剂量药物,也无法控制患者的心绞痛,患者忍受日常疼痛的唯一方法是使用阿片类药物。因此,考虑采用替代疗法为这些患者提供缓解。
使用硬膜外电极进行SCS,刺激心绞痛感知区域的感觉异常。
先前接受硬膜外导管治疗的患者在刺激幅度、电极迁移频率和SCS效果方面的差异。
先前较长时间(1 - 36个月)接受硬膜外导管治疗的患者组在刺激需求(p = 0.09)、电极迁移频率(p = 0.46)和止痛效果(p = 0.16)方面无差异。
先前接受硬膜外导管治疗的患者接受SCS的效果与其他患者相同。