链球菌脱氧核糖核酸酶B在免疫学上与超抗原SpeF相同，但涉及不同的结构域。
Streptococcal DNase B is immunologically identical to superantigen SpeF but involves separate domains.
作者信息
Eriksson A, Eriksson B, Holm S E, Norgren M
机构信息
Department of Clinical Bacteriology, Umeå University, S-901 85 Umeå, Sweden.
出版信息
Clin Diagn Lab Immunol. 1999 Jan;6(1):133-6. doi: 10.1128/CDLI.6.1.133-136.1999.
Abstract
The previous suggestion that streptococcal superantigen SpeF might be identical to DNase B was confirmed in this study. Polyclonal SpeF-specific antisera were able to inhibit depolymerization of methyl-green DNA by DNase B. However, T-cell mitogenicity and nuclease activity appear to involve separate immune epitopes on SpeF, since sera with the capacity to neutralize the mitogenic activity of SpeF did not always inhibit the DNase activity.
摘要
本研究证实了之前关于链球菌超抗原SpeF可能与DNase B相同的推测。多克隆SpeF特异性抗血清能够抑制DNase B对甲基绿DNA的解聚作用。然而，T细胞促有丝分裂活性和核酸酶活性似乎涉及SpeF上不同的免疫表位，因为具有中和SpeF促有丝分裂活性能力的血清并不总是抑制DNase活性。
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