Lee Sung Ok, Choi Sang Zin, Choi Sang Un, Lee Kang Choon, Chin Young Won, Kim Jinwoong, Kim Young Choong, Lee Kang Ro
College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea, Korea Research Institute of Chemical Technology, Taejeon 305-600, Korea.
J Nat Prod. 2005 Oct;68(10):1471-4. doi: 10.1021/np058044e.
Three new labdane diterpenes (1-3), together with eight known diterpenoids, were isolated from a methanol extract of the aerial parts of Aster spathulifolius. The structures of 1-3 were determined as (13R)-labda-7,14-diene 13-O-beta-d-(4'-O-acetyl)fucopyranoside (1), (13R)-labda-7,14-diene 13-O-beta-d-(3'-O-acetyl)fucopyranoside (2), and (13R)-labda-14(15)-en-8,13-diol 13-O-beta-d-fucopyranoside (3), on the basis of spectroscopic and chemical methods. Compounds 1, 2, and four of the known compounds exhibited generally nonspecific cytotoxicity against human A549, SK-OV-3, SK-MEL-2, XF498, and HCT15 tumor cells.
从匙叶紫菀地上部分的甲醇提取物中分离出三种新的半日花烷二萜（1-3）以及八种已知的二萜类化合物。基于光谱和化学方法，确定1-3的结构分别为（13R）-半日花-7,14-二烯13-O-β-d-（4'-O-乙酰基）岩藻糖吡喃糖苷（1）、（13R）-半日花-7,14-二烯13-O-β-d-（3'-O-乙酰基）岩藻糖吡喃糖苷（2）和（13R）-半日花-14（15）-烯-8,13-二醇13-O-β-d-岩藻糖吡喃糖苷（3）。化合物1、2以及四种已知化合物对人A549、SK-OV-3、SK-MEL-2、XF498和HCT15肿瘤细胞普遍表现出非特异性细胞毒性。
