Cheon S H, Park J S, Chung B H, Choi B G, Cho W J, Choi S U, Lee C O
College of Pharmacy, Chonnam National University, Kwangju, Korea.
Arch Pharm Res. 1998 Apr;21(2):193-7. doi: 10.1007/BF02974027.
A number of substituted isoquinolin-1-ones, possible bioisosteres of the 5-aryl substituted 2,3-dihydroimidazo[2,1-a]isoquinolines, were synthesized and tested for their antitumor activity against five different human tumor cell lines. O-(3-hydroxypropyl) substituted compound (15) exhibited the best antitumor activity which is 3-5 times better than 5-[4'-(piperidinomethyl) phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline (1).
