Synthesis and structure-activity relationship studies of substituted isoquinoline analogs as antitumor agent.
作者信息
Cheon S H, Park J S, Chung B H, Choi B G, Cho W J, Choi S U, Lee C O
机构信息
College of Pharmacy, Chonnam National University, Kwangju, Korea.
出版信息
Arch Pharm Res. 1998 Apr;21(2):193-7. doi: 10.1007/BF02974027.
PMID:9875430
Abstract
A number of substituted isoquinolin-1-ones, possible bioisosteres of the 5-aryl substituted 2,3-dihydroimidazo[2,1-a]isoquinolines, were synthesized and tested for their antitumor activity against five different human tumor cell lines. O-(3-hydroxypropyl) substituted compound (15) exhibited the best antitumor activity which is 3-5 times better than 5-[4'-(piperidinomethyl) phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline (1).
摘要
Zotero 插件