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Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents.

作者信息

Cho W J, Park M J, Chung B H, Lee C O

机构信息

College of Pharmacy, Chonnam National University, Buk-gu, Kwangju, Korea.

出版信息

Bioorg Med Chem Lett. 1998 Jan 6;8(1):41-6. doi: 10.1016/s0960-894x(97)10190-1.

DOI:10.1016/s0960-894x(97)10190-1
PMID:9871625
Abstract

To investigate the structure-activity relationship of 7,8-dimethoxy-2- methyl-3-(4,5-methylenedioxy-2-vinylphenyl)isoquinolin-1(2H) -one 2, diverse substituted 3-arylisoquinolines were synthesized and tested in vitro antitumor activity against five human tumor cell lines. The results showed a broad antitumor spectrum for a series of 3-arylisoquinolines.

摘要

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