Kim Y S, Pyo M K, Park K M, Hahn B S, Yang K Y, Yun-Choi H S
Natural Products Research Institute, Seoul National University, Korea.
Arch Pharm Res. 1998 Aug;21(4):374-7. doi: 10.1007/BF02974629.
The freeze-dried powder of Lumbricus rubellus earthworm was administered orally to rats and its fibrinolytic and antithrombotic effects were investigated. The fibrinolytic activity of plasma was determined by measuring the plasmin activity of the euglobulin fraction and was increased to two-folds of the control at a dose of 0.5 g/kg/day and five times with 1 g/kg/day after 4-day administration. The antithrombotic effect was studied in an arterio-venous shunt model of rats. The thrombus weight decreased significantly from 43.2 mg to 32.4 mg at a dose of 0.5 g/kg/day after 8-day treatment. The level of fibrinogen/fibrin degradation product (FDP) in serum was elevated in a dose-dependent manner during the treatment period. On the 8th day after administration, the FDP value was increased to 7.7 micrograms/ml compared with the control value of 3.3 micrograms/ml. These results support that earthworm powder is valuable for the prevention and/or treatment of thrombotic conditions.
将赤子爱胜蚓冻干粉末经口给予大鼠，并研究其纤溶和抗血栓作用。通过测量优球蛋白组分的纤溶酶活性来测定血浆的纤溶活性，给药4天后，剂量为0.5 g/kg/天时，血浆纤溶活性增加至对照的两倍，剂量为1 g/kg/天时增加至五倍。在大鼠动静脉分流模型中研究抗血栓作用。治疗8天后，剂量为0.5 g/kg/天时，血栓重量从43.2 mg显著降至32.4 mg。治疗期间，血清中纤维蛋白原/纤维蛋白降解产物（FDP）水平呈剂量依赖性升高。给药第8天，FDP值从对照值3.3微克/毫升增加至7.7微克/毫升。这些结果支持蚯蚓粉对血栓形成疾病的预防和/或治疗具有重要价值。
