Institute for Medical Research and Occupational Health, 2 Ksaverska Road, Croatia.
Eur Rev Med Pharmacol Sci. 2011 Jan;15(1):71-8.
A balance between fibrinolysis and coagulation is crucial for maintaining haemostasis. A haemostatic disorder leads to various physiological changes and causes different diseases. Glycolipoprotein mixture (G-90), prepared from the tissue homogenate of the earthworm Eisenia foetida, was examined in vivo, in an animal study (conducted on Wistar rats) in order to determine its fibrinolytic and anticoagulation activity.
The influence of G-90 treatment on haematological and homeostatic parameters was monitored as well.
Statistical analysis has shown the most pronounced effect of G-90 to be exerted on bleeding and coagulation times; the effects in reference were proven to be statistically significant (p = 0.03 and 0.005, respectively). A statistically significant effect of G-90 was also seen with thrombin time (p = 0.02) and plasminogen level (p = 0.004).
The results have shown the influence of G-90 on blood coagulation to be very similar to that of heparin, a known anticoagulant. Thus G-90 could be considered as a new thrombolytic agent of use in veterinary and human medicine.
纤维蛋白溶解和凝血之间的平衡对于维持止血至关重要。止血紊乱会导致各种生理变化，并导致不同的疾病。糖脂混合物（G-90）是从赤子爱胜蚓组织匀浆中制备的，在一项动物研究（在 Wistar 大鼠上进行）中进行了体内检查，以确定其纤维蛋白溶解和抗凝活性。
还监测了 G-90 处理对血液学和体内平衡参数的影响。
统计分析表明，G-90 对出血和凝血时间的影响最为显著；参考中的效果被证明具有统计学意义（分别为 p = 0.03 和 0.005）。G-90 对凝血酶时间（p = 0.02）和纤溶酶原水平（p = 0.004）也有统计学显著影响。
结果表明，G-90 对血液凝固的影响与已知的抗凝剂肝素非常相似。因此，G-90 可以被认为是一种新的溶栓剂，可用于兽医和人类医学。
