Cheong H, Ryu S Y, Oak M H, Cheon S H, Yoo G S, Kim K M
College of Pharmacy, Chonnam National University, Kwang-Ju, Korea.
Arch Pharm Res. 1998 Aug;21(4):478-80. doi: 10.1007/BF02974647.
The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 microM.
通过测定脱颗粒的IC50值，研究了黄酮类化合物抗过敏作用的构效关系。采用RBL-2H3细胞中己糖胺酶的释放（脱颗粒标志物）来评估抗过敏作用。在测试的22种黄酮类化合物中，木犀草素、芹菜素、香叶木素、漆黄素和槲皮素活性最强，IC50值小于10微摩尔。
